Real-Time Randomization
A tool for randomising subjects one at a time as they enrol in a clinical trial — the realistic scenario where you don't know all participants in advance.
What it does
- Assigns each enrolling subject to a treatment arm using the chosen randomisation method
- Maintains a running log of all allocations
- Keeps the allocation sequence concealed (next assignment generated on demand)
This supports proper allocation concealment — a key safeguard against selection bias, because the person enrolling subjects cannot predict the next assignment.
Randomisation methods
| Method | What it does |
|---|---|
| Simple | Independent random assignment (like a coin flip) |
| Block | Randomised within blocks to keep groups balanced |
| Stratified | Separate randomisation within strata |
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